Related Experiment Video
Updated: Jun 27, 2026
06:18
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Possible risk factor for postmenopausal women: postprandial hypertriglyceridemia
Remi Yoshikata1, Yuko Miyahara, Yoshiko Onoe
1Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan. r-yoshik@obgy.twmu.ac.jp
The Journal of Obstetrics and Gynaecology Research
|November 18, 2008
Summary
Postprandial hypertriglyceridemia is common in postmenopausal Japanese women and may indicate altered lipid metabolism. Measuring postprandial triglycerides offers better insights than fasting levels alone.
Area of Science:
- Endocrinology
- Lipid Metabolism
- Women's Health
Background:
- Postmenopausal women are at increased risk for cardiovascular disease.
- Lipid metabolism changes significantly after menopause.
- Postprandial hypertriglyceridemia (PHTG) is an emerging risk factor.
Purpose of the Study:
- To investigate the clinical implications of PHTG in postmenopausal Japanese women.
- To assess the relationship between PHTG and other lipid parameters.
Main Methods:
- Collected fasting and postprandial blood samples from 91 postmenopausal Japanese women.
- Categorized participants based on fasting and postprandial triglyceride (TG) levels.
- Analyzed lipid profiles, including TG and high-density lipoprotein cholesterol (HDL-C).
Main Results:
- Nearly 50% of women had normal fasting TG but elevated postprandial TG.
- PHTG was negatively correlated with HDL-C, unlike fasting TG.
- Approximately 10% of women exhibited hypertriglyceridemia based on fasting TG.
Conclusions:
- PHTG is prevalent in this population and may be a more sensitive indicator of dyslipidemia than fasting TG.
- Measuring postprandial TG provides a more comprehensive understanding of lipid metabolism in postmenopausal women.
Related Concept Videos
01:29Hyperglycemia
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
01:26Type II Diabetes I: Introduction
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
01:29Cholesterol: Significance and Regulation
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:24Overview of Lipid Metabolism
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...