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Internally self-assembled particles entrapped in thermoreversible hydrogels.

Samuel Guillot1, Matija Tomsic, Laurent Sagalowicz

  • 1Institute of Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria.

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|November 18, 2008
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Summary

This study developed thermogelling emulsions using kappa-carrageenan hydrogels to encapsulate internally self-assembled structures (ISAsomes). Temperature changes reversibly gel the system without altering droplet size, offering controlled delivery potential.

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Area of Science:

  • Materials Science
  • Colloid and Surface Chemistry
  • Biotechnology

Background:

  • Internally self-assembled structures (ISAsomes) like cubosomes and hexosomes offer unique nanostructured delivery vehicles.
  • Thermosensitive hydrogels can provide controlled release and stimuli-responsive systems.
  • Combining ISAsomes with thermoreversible hydrogels presents opportunities for advanced formulations.

Purpose of the Study:

  • To develop thermogelling emulsions by entrapping ISAsomes within a kappa-carrageenan hydrogel.
  • To investigate the thermoreversible behavior and structural integrity of ISAsomes within the hydrogel matrix.
  • To explore the influence of the hydrogel network on the internal nanostructure of ISAsomes.

Main Methods:

  • Preparation of thermogelling emulsions with entrapped ISAsomes (cubosomes, hexosomes, micro-emulsions).
  • Utilizing Small-Angle X-ray Scattering (SAXS) to analyze internal nanostructures and phase behavior.
  • Temperature cycling (above and below 60°C) to assess thermoreversible gelation and structural stability.

Main Results:

  • A fluid system above 60°C transitions to a physical gel entrapping ISAsomes below 60°C.
  • Temperature cycling did not affect the size of the entrapped ISAsomes.
  • The kappa-carrageenan network influenced ISAsome phase behavior, potentially shifting phase borders and inducing transformations (e.g., micro-emulsions to cubosomes).
  • Hexosome lattice parameters were slightly modified by the hydrogel network.

Conclusions:

  • Kappa-carrageenan hydrogels can effectively encapsulate ISAsomes, creating thermogelling delivery systems.
  • The developed system exhibits reversible gelation upon temperature change, preserving ISAsome integrity.
  • The hydrogel network can modulate the internal nanostructure of ISAsomes, offering a means to tune their properties for specific applications.