Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
Portal Hypertension01:22

Portal Hypertension

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thrombosis and anticoagulation in patients with Cirrhosis. An overview.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same author

Hepatic vein thrombosis and PVT: A personal view on the contemporary development of ideas.

Clinical liver disease·2024
Same author

Primary Budd-Chiari Syndrome. Reply.

The New England journal of medicine·2023
Same author

Primary Budd-Chiari Syndrome.

The New England journal of medicine·2023
Same author

Contrast-enhanced CT and liver surface nodularity for the diagnosis of porto-sinusoidal vascular disorder: A case-control study.

Hepatology (Baltimore, Md.)·2022
Same author

Paroxysmal nocturnal hemoglobinuria and vascular liver disease: Eculizumab therapy decreases mortality and thrombotic complications.

American journal of hematology·2022
Same journal

Anserine restores antibacterial immunity in cirrhosis via a protective CCL5-mediated hepatocyte-CD44<sup>+</sup>pDC crosstalk.

Journal of hepatology·2026
Same journal

Anti-CCL2-conjugated platelets attenuate early allograft and ischemia-reperfusion injury by inhibiting monocyte infiltration.

Journal of hepatology·2026
Same journal

A precision randomized trial of hepatitis C treatment support among people who inject drugs in India: The STOP-C Trial.

Journal of hepatology·2026
Same journal

Response to "Single-nucleus and spatial transcriptomic analyses reveal intra-tissue heterogeneity of PNPLA3".

Journal of hepatology·2026
Same journal

One-stop liquid biopsy: Can a single blood sample reveal the full spectrum of liver disease?

Journal of hepatology·2026
Same journal

Nocturnal insulin resistance and reduced insulin availability in human MASLD.

Journal of hepatology·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Primary Budd-Chiari syndrome.

Dominique-Charles Valla1

  • 1Centre de Référence des Maladies Vasculaires du Foie, AP-HP, Hôpital Beaujon, Service d'Hépatologie, Clichy 92118, France. dominique.valla@bjn.aphp.fr

Journal of Hepatology
|November 18, 2008
PubMed
Summary
This summary is machine-generated.

Primary Budd-Chiari syndrome, a blockage in hepatic veins, affects young adults and is often linked to myeloproliferative diseases. Early diagnosis and a staged treatment strategy significantly improve survival rates.

More Related Videos

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Related Experiment Videos

Last Updated: Jun 27, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Area of Science:

  • Hepatology
  • Vascular Medicine
  • Hematology

Background:

  • Primary Budd-Chiari syndrome involves hepatic venous outflow tract obstruction due to thrombosis or fibrosis.
  • This rare condition primarily affects young adults and presents with diverse symptoms, necessitating consideration in all liver disease cases.
  • Identified risk factors, frequently co-occurring, include myeloproliferative diseases, diagnosed via JAK2 V617F mutation or bone marrow biopsy.

Purpose of the Study:

  • To summarize the diagnostic considerations and current therapeutic strategies for primary Budd-Chiari syndrome.
  • To highlight the importance of identifying underlying risk factors, particularly myeloproliferative neoplasms.
  • To present an evidence-based treatment algorithm and its impact on patient survival.

Main Methods:

  • Review of diagnostic imaging techniques including Doppler-ultrasound, CT, and MRI for identifying venous obstruction and collaterals.
  • Genetic testing for Janus tyrosine kinase-2 (JAK2) V617F mutation and bone marrow biopsy for diagnosing myeloproliferative diseases.
  • Analysis of a proposed therapeutic strategy involving anticoagulation, risk factor management, diuretics, angioplasty, TIPS, and liver transplantation.

Main Results:

  • Diagnostic imaging effectively visualizes the hepatic venous obstruction and collateral circulation.
  • A staged therapeutic approach, starting with conservative measures and progressing to interventions like TIPS and transplantation, has achieved 5-year survival rates nearing 90%.
  • Prognosis is influenced by liver disease severity, with long-term risks including underlying condition transformation and hepatocellular carcinoma.

Conclusions:

  • Early consideration of Budd-Chiari syndrome in patients with liver disease is crucial.
  • A multi-faceted treatment strategy tailored to patient response significantly enhances survival outcomes.
  • Long-term surveillance is necessary to monitor for disease progression and potential complications.