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Synthesis and antibacterial activity of new C-10 quinolonyl-cephem esters
T P Demuth1, R E White, R A Tietjen
1Norwich Eaton Pharmaceuticals, Inc., Procter & Gamble Company, Norwich, New York 13815.
The Journal of Antibiotics
|February 11, 1991
Abstract:
A series of cephalosporins derived from cephalothin containing an ester-linked quinolonyl substituent at the C-10 position (C-10 quinolonyl-cephem esters) has been prepared and evaluated for in vitro antibacterial activity. The C-10 quinolonyl-cephem esters exhibited a broadened spectrum of activity when compared with cephalothin and the corresponding quinolones, including activity against beta-lactamase-producing bacteria.