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Updated: Jun 27, 2026
12:22
The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
[Papillary renal cell carcinoma spectrum].
Actas Urologicas Espanolas
|November 19, 2008
Summary
The classification of papillary renal cell carcinoma is expanding due to new molecular and morphological data. This includes numerous new subtypes and genetic associations, highlighting the evolving nature of renal cancer diagnosis.
Area of Science:
- Renal oncology and pathology
- Molecular genetics of cancer
- Tumor classification systems
Context:
- The 2004 World Health Organization (WHO) classification of renal tumors in adults reflects advances in understanding renal cancer.
- Morphological and molecular data are crucial for defining new tumor entities.
- Ongoing discoveries in molecular genetics necessitate continuous updates to cancer classifications.
Purpose:
- To review the expanding spectrum of papillary renal cell carcinoma (PRCC).
- To highlight the heterogeneity in genetic background and phenotype within PRCC.
- To discuss newly described entities and their relationship to established PRCC categories.
Summary:
- Papillary renal cell carcinoma (PRCC) encompasses a wide and heterogeneous group of neoplasms.
- This includes conventional sporadic forms, hereditary syndromes, and specific genetic disorders.
- Distinct morphological variants and recently included entities like tubulo-cystic carcinoma further broaden the PRCC classification.
Impact:
- The classification of PRCC is progressively expanding with new, sometimes poorly defined, entities.
- Future discoveries in molecular pathology will continue to refine and enlarge the PRCC group.
- Pathologists play a critical role in identifying and integrating these new renal cancer classifications.
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