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Related Concept Videos

Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
Classification of Epithelial Tissues: Simple Epithelium01:30

Classification of Epithelial Tissues: Simple Epithelium

Simple epithelium consists of a single layer of cells that lines body cavities and blood vessels. The shape of the cells in the epithelium reflects the function of the tissue. Cells in simple squamous epithelium appear as thin scales with flat, elliptical nuclei that mirror the form of the cell.
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
Classification of Epithelial Tissues: Stratified Epithelium01:29

Classification of Epithelial Tissues: Stratified Epithelium

Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

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Related Experiment Video

Updated: Jun 27, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Classification of tumours.

Helge L Waldum1, Arne K Sandvik, Eiliv Brenna

  • 1Norwegian University of Science and Technology, Department of Cancer Research and Molecular Medicine, Trondheim University Hospital, NO-7006 Trondheim, Norway. helge.waldum@ntnu.no

Journal of Experimental & Clinical Cancer Research : CR
|November 19, 2008
PubMed
Summary
This summary is machine-generated.

Understanding tumourigenesis requires identifying the cell of origin. Precise tumour classification based on cell type, not just differentiation, is crucial for effective prevention and treatment strategies.

Related Experiment Videos

Last Updated: Jun 27, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • Current tumour classification relies on the most differentiated cells, with exceptions for neuroendocrine differentiation.
  • Normal neuroendocrine cells can divide, and their continuous stimulation can lead to increasingly malignant tumour formation.
  • Recognizing the specific cell of origin is vital for understanding tumourigenesis and developing targeted therapies.

Purpose of the Study:

  • To emphasize the importance of identifying the precise cell of origin for tumour classification.
  • To highlight how understanding cell growth regulation can inform tumour prevention and treatment.
  • To advocate for a shift towards classifying tumours based on their originating cell type.

Main Methods:

  • Review of current tumour classification practices.
  • Analysis of neuroendocrine cell behaviour and tumourigenesis.
  • Case study of gastrointestinal stromal tumour treatment efficacy based on cellular classification.

Main Results:

  • Tumour classification may misidentify cancers with neuroendocrine differentiation.
  • Continuous stimulation of normal neuroendocrine cells can drive tumour progression.
  • Accurate cellular classification is essential for successful targeted cancer therapies.

Conclusions:

  • Future tumour classification should precisely identify the originating cell type, not just the degree of differentiation.
  • This refined classification will improve understanding of tumour development and enable better prevention and treatment strategies.
  • The example of gastrointestinal stromal tumours demonstrates the clinical impact of precise cellular classification.