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Related Experiment Video

Updated: Jun 27, 2026

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex
16:45

Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex

Published on: March 13, 2016

Cone inputs to murine striate cortex.

Björn Ekesten1, Peter Gouras

  • 1Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden. bjorn.ekesten@kv.slu.se

BMC Neuroscience
|November 19, 2008
PubMed
Summary

Most mouse visual cortex neurons respond to both UV and middle wavelength light, suggesting limited color vision. A small percentage of cells show spectral selectivity, indicating rare potential for chromatic contrast detection in mice.

Area of Science:

  • Neuroscience
  • Visual System Research
  • Mammalian Vision

Background:

  • Investigating the functional role of cone photoreceptor mechanisms in the murine visual cortex.
  • Examining potential for color vision in mice based on neural responses.
  • Utilizing specific light stimuli to target ultra-violet (UV) and middle wavelength sensitive (M) cone opsins.

Purpose of the Study:

  • To determine the effectiveness of UV and M cone inputs in the murine visual cortex.
  • To identify unique cone input selectivity in the visual system of mice.
  • To assess the neural basis for potential color vision in mice.

Main Methods:

  • Recording single neuron responses in the murine visual cortex.
  • Stimulating each eye with diffuse 370 nm (UV cone) and 505 nm (M cone) light.

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  • Employing a strong adapting light to suppress rod photoreceptor activity.

    • Main Results:

    • Single cells in the striate cortex responded to both spectral stimuli.
    • Two main cell types were identified: those with low spontaneous activity and transient responses, and those with spontaneous activity and tonic responses.
    • Most cells responded similarly to both UV and M cone stimuli; a small fraction (6%) showed spectral selectivity or opponent responses.

    Conclusions:

    • The majority of murine striate cortex cells receive excitatory input from both UV and M cones.
    • A small subset of neurons exhibits selectivity for a single cone type or spectrally opponent responses.
    • While cells potentially underlying chromatic contrast detection exist, they are rare in the murine striate cortex.