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Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...
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Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
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Related Experiment Video

Updated: Jun 27, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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Published on: August 18, 2020

[Psychosis in affective disorders].

Lars Vedel Kessing1

  • 1Psykiatrisk Center, Rigshospitalet, Afsnit 6233, DK-2100 København Ø. lars.kessing@rh.regionh.dk

Ugeskrift for Laeger
|November 19, 2008
PubMed
Summary
This summary is machine-generated.

Psychosis in affective disorders, including depression and mania, is common and linked to poor outcomes. Its relationship to other psychotic disorders remains unclear.

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Context:

  • Psychosis is a significant feature in affective disorders, affecting 15-20% of depressive patients and 50% of manic patients.
  • The presence of psychotic features in affective disorder is associated with a poorer prognosis, particularly in depression.

Purpose:

  • To review the prevalence and implications of psychosis in affective disorders.
  • To discuss the diagnostic challenges and unresolved questions regarding the relationship between psychosis in affective disorders, schizoaffective disorder, and schizophrenia.

Summary:

  • Psychotic features are common in both depression and mania.
  • Affective disorder with psychosis carries a worse prognosis, increasing risks for recurrence, bipolar disorder development, and suicide in depressive cases.
  • The precise nosological classification and relationship of psychosis in affective disorder to schizophrenia and schizoaffective disorder are subjects of ongoing debate.

Impact:

  • Highlights the clinical significance of psychosis in affective disorders.
  • Underscores the need for further research into the etiology and classification of these conditions.
  • Informs clinical practice regarding the prognosis and management of patients with affective disorders and psychotic features.