Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reconstruction of septin higher-order nano-size structures in ovarian cancer cells uncover susceptibility to the septin-targeting small molecule UR214-9.

bioRxiv : the preprint server for biology·2026
Same author

Comparative Evaluation of Twin Block and Forsus Fatigue Resistant Device in the Management of Class II Malocclusion: A Systematic Review.

Cureus·2026
Same author

IL1β/IL1R1/IRAK4 Drives Inflammatory Ovarian Cancer Seeding at the inflamed sites and Is Reversed by an IRAK4 inhibitor UR241-2.

bioRxiv : the preprint server for biology·2026
Same author

Six-Month Outcomes in Children With COVID-19 or Multisystem Inflammatory Syndrome in Children.

Hospital pediatrics·2026
Same author

Isoform-Specific Functions of p73 Drive Survival and Chemoresistance in Diffuse Large B-Cell Lymphoma.

bioRxiv : the preprint server for biology·2026
Same author

Differential response of finger millet accessions to contrasting saline water levels and irrigation regimes under desert conditions.

Frontiers in plant science·2026

Related Experiment Video

Updated: Jun 27, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

Alkaloids: future prospective to combat leishmaniasis.

Bhuwan B Mishra1, Raju R Kale, Rakesh K Singh

  • 1Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India.

Fitoterapia
|November 19, 2008
PubMed
Summary

Leishmaniasis treatment faces challenges due to drug resistance. This review explores plant-derived alkaloids as promising, effective antileishmanial agents, offering a potential new therapeutic avenue.

More Related Videos

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
12:22

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line

Published on: December 30, 2012

Development of Leishmania Species Strains with Constitutive Expression of eGFP
10:03

Development of Leishmania Species Strains with Constitutive Expression of eGFP

Published on: April 21, 2023

Related Experiment Videos

Last Updated: Jun 27, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
12:22

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line

Published on: December 30, 2012

Development of Leishmania Species Strains with Constitutive Expression of eGFP
10:03

Development of Leishmania Species Strains with Constitutive Expression of eGFP

Published on: April 21, 2023

Area of Science:

  • Tropical medicine
  • Parasitology
  • Pharmacology

Background:

  • Leishmaniasis is a significant tropical disease caused by Leishmania parasites infecting macrophages.
  • Pentavalent antimonials are traditional treatments but face increasing drug resistance.
  • Alternative drugs like amphotericin B and miltefosine have safety limitations.

Purpose of the Study:

  • To review the current status of leishmaniasis, including its synergy with HIV.
  • To summarize available therapeutic options for leishmaniasis.
  • To highlight alkaloids from plant sources with significant antileishmanial activity.

Main Methods:

  • Literature review of scientific articles on leishmaniasis and antileishmanial agents.
  • Focus on research identifying plant-derived compounds, particularly alkaloids.
  • Analysis of studies reporting the efficacy of alkaloids against Leishmania parasites.

Main Results:

  • Pentavalent antimonials, while cost-effective, exhibit growing resistance.
  • Second-line drugs lack ideal safety profiles.
  • Numerous plant-derived alkaloids demonstrate potent antileishmanial activity in research.

Conclusions:

  • Plant-derived alkaloids represent a promising source for novel leishmaniasis drug development.
  • Alkaloids show significant potential to overcome existing drug resistance issues.
  • Further research into alkaloids could lead to safer and more effective leishmaniasis therapies.