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Related Concept Videos

Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...

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Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes
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Influenza sequence and epitope database.

In Seok Yang1, Joo-Yeon Lee, Joon Seung Lee

  • 1Department of Biotechnology & Bioinformatics, College of Science & Technology, Korea University, Chungnam, Korea.

Nucleic Acids Research
|November 19, 2008
PubMed
Summary
This summary is machine-generated.

A new database, the Influenza Sequence and Epitope Database (ISED), catalogs Asian influenza virus genomes. This resource aids in monitoring viral evolution and emergence for public health.

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Area of Science:

  • Virology
  • Bioinformatics
  • Epidemiology

Background:

  • Influenza epidemics are driven by viral genetic changes that evade host immunity.
  • Recent years have seen an increase in sequenced influenza virus genomes from Asia.
  • Understanding Asian influenza virus genomes is crucial for tracking strain emergence, migration, and evolution.

Purpose of the Study:

  • To develop an integrated, user-friendly relational database for influenza sequence and epitope information from Asia.
  • To facilitate the analysis and visualization of influenza virus genomic data.

Main Methods:

  • Development of the Influenza Sequence and Epitope Database (ISED).
  • Cataloging of influenza A and B virus sequences and epitope data from 17 countries, including 9 Asian nations.
  • Inclusion of amantadine-resistant influenza virus sequences from Korea.

Main Results:

  • ISED hosts 13,020 influenza A and 2,984 influenza B virus sequences.
  • The database contains approximately 545 amantadine-resistant influenza virus sequences from Korea.
  • ISED offers tools for sequence alignment, pattern analysis, and epitope-matching structure visualization.

Conclusions:

  • The Influenza Sequence and Epitope Database (ISED) provides a valuable resource for studying influenza virus evolution in Asia.
  • ISED supports monitoring and understanding of influenza epidemics through accessible genomic and epitope data.
  • The database is freely available online, promoting collaborative research and public health surveillance.