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Related Experiment Video

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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

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Genetic association analysis with FAMHAP: a major program update.

Christine Herold¹, Tim Becker

¹Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany. herold@imbie.meb.uni-bonn.de

Bioinformatics (Oxford, England)

|November 19, 2008

Summary

FAMHAP software now supports case-control data and genome-wide association studies (GWAS) with its new update and the runFamhap program. A graphical user interface (GUI) enhances usability for flexible haplotype analysis.

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Area of Science:

Genetics
Bioinformatics

Background:

FAMHAP is a software tool for haplotype association analysis in nuclear families.
A significant update introduces new features for case-control data analysis.
The availability of the software is detailed at http://famhap.meb.uni-bonn.de.

Purpose of the Study:

To introduce a major update to FAMHAP software with enhanced capabilities.
To present the new runFamhap program for repeated analysis across genetic marker sets.
To describe the development of a platform-independent graphical user interface (GUI) for improved usability.

Main Methods:

Incorporation of new features for case-control data analysis within FAMHAP.
Development of the runFamhap program to automate repetitive analyses.
Implementation of a user-friendly, platform-independent GUI for both FAMHAP and runFamhap.
Application of FAMHAP and runFamhap to HapMap data for demonstration.

Main Results:

FAMHAP now accommodates case-control association studies.
The runFamhap program enables flexible genome-wide haplotype analysis, facilitating GWAS.
The new GUI simplifies the utilization of FAMHAP and runFamhap.

Conclusions:

The updated FAMHAP software, along with runFamhap and a new GUI, significantly enhances haplotype association analysis capabilities.
These advancements streamline the application of FAMHAP for genome-wide association studies (GWAS).
The software provides a flexible and user-friendly platform for genetic marker analysis.