Related Experiment Video
Updated: Jun 27, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
Validation of a prediction rule for development of rheumatoid arthritis in patients with early undifferentiated
B Kuriya1, C K Cheng, H M Chen
1Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Wolf and Lebovic Building, 60 Murray Street, Box 11, 2nd floor, Toronto, Ontario M5T 3L9, Canada. bindee.kuriya@gmail.com
Objective:
To validate a model which predicts progression from undifferentiated arthritis (UA) to RA, in a Canadian UA cohort.
Methods:
The prediction rule, comprising variables which are scored from 0 to 13, with higher scores reflecting an increased risk of RA, was applied to baseline characteristics of all patients with UA. Progression to RA was determined at 6 months.
Results:
105 patients were identified. By 6 months, 80 (76%) had developed RA while 25 (24%) had developed another diagnosis. Number of tender and swollen joints, rheumatoid factor positivity, anti-cyclic citrullinated peptide positivity, poor functional status and high disease activity were associated with development of RA (p<0.01). Median prediction score was 8.0 for progressors, 5.0 for non-progressors. With these cut-off points, 18 (72%) patients with scores < or =5 did not develop RA, while 35 (97%) with scores > or =8 did develop RA.
Conclusions:
High scores in our cohort predicted those who progressed to RA by 6 months. Baseline scores > or =8 corresponded with higher rates of progression.
Related Concept Videos
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Rheumatic Heart Disease I: Introduction
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
The JAK-STAT Signaling Pathway
