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Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Inflammation01:38

Inflammation

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Can HDL cholesterol be replaced by paraoxonase 1 activity in the prediction of severe coronary artery disease in patients with type 2 diabetes?

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Related Experiment Video

Updated: Jun 27, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

High-density lipoprotein: why all the fuss?

Bharti Mackness1, Mike Mackness

  • 1Pontech House, Cote Green Road, Marple Bridge, Stockport SK6 5EW, UK.

Annals of Clinical Biochemistry
|November 19, 2008
PubMed
Summary

New coronary heart disease treatments focusing on raising HDL-cholesterol may fail. Instead, targeting specific antiatherosclerotic components of HDL is a more promising approach for cardiovascular disease prevention.

Area of Science:

  • Cardiovascular Science
  • Biochemistry
  • Pharmacology

Background:

  • Coronary heart disease (CHD) treatments often aim to increase high-density lipoprotein (HDL)-cholesterol.
  • The failure of CETP inhibitor torcetrapib highlights potential issues with this strategy.

Purpose of the Study:

  • To review the antiatherosclerotic properties of HDL.
  • To evaluate strategies for increasing HDL-cholesterol concentration.
  • To propose an alternative therapeutic approach for CHD.

Main Methods:

  • Review of existing literature on HDL function and cholesterol-raising therapies.
  • Analysis of the relationship between HDL-cholesterol levels and protective functions.
  • Critical assessment of the CETP inhibitor torcetrapib's clinical trial outcomes.

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High-Density Lipoprotein-Specific Phospholipid Efflux Assay
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High-Density Lipoprotein-Specific Phospholipid Efflux Assay

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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Related Experiment Videos

Last Updated: Jun 27, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Main Results:

  • HDL possesses significant antiatherosclerotic properties.
  • HDL-cholesterol concentration does not accurately reflect HDL's protective capacity.
  • Current strategies focused solely on increasing HDL-cholesterol may be ineffective.

Conclusions:

  • Rethinking the approach to CHD treatment is necessary.
  • Targeting specific antiatherosclerotic components within HDL particles is a more viable strategy.
  • Future research should focus on the functional aspects of HDL rather than just cholesterol levels.