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Published on: January 28, 2020
Elevated serum C-reactive protein levels predict cardiovascular events in the Japanese coronary artery disease (JCAD)
Kenei Shimada1, Masatoshi Fujita, Atsushi Tanaka
1Department of Cardiology, Osaka Ekisaikai Hospital, Osaka, Japan.
Insights
Elevated C-reactive protein (CRP) levels predict cardiovascular events in Japanese patients with coronary artery disease (CAD). This finding highlights CRP as a key biomarker for risk stratification in this population.
Area of Science:
- Cardiology
- Biomarkers
- Epidemiology
Background:
- C-reactive protein (CRP) is a known predictor of atherosclerotic vascular disease in Caucasian populations.
- The role of CRP in cardiovascular events among Japanese patients with coronary artery disease (CAD) requires further investigation.
Purpose of the Study:
- To investigate the association between serum CRP levels and cardiovascular events in Japanese patients diagnosed with CAD.
Main Methods:
- The Japanese CAD (JCAD) study included 6,802 patients with significant coronary artery stenosis (>or=75%).
- Patients were followed for a mean of 2.7 years, with a follow-up rate of 88.3%.
- Statistical analyses included Kaplan-Meier and Cox proportional hazard models, adjusting for baseline covariates.
Main Results:
- A serum CRP level of >=0.1 mg/dl was associated with a 30% higher rate of all cardiovascular events (P=0.0002).
- Elevated CRP (>=0.1 mg/dl) independently predicted all events (P=0.0001), cardiac events, and cardiac death (P=0.0005).
Conclusions:
- Elevated serum CRP levels are an independent predictor of cardiovascular events in Japanese patients with CAD.
- CRP serves as a valuable prognostic biomarker for cardiovascular risk in this specific patient group.
Background:
Accumulating evidence indicates that C-reactive protein (CRP) is an independent predictive factor for atherosclerotic vascular disease in Caucasians. Accordingly, this study sought to investigate the relationship between the serum level of CRP and cardiovascular events of Japanese patients with coronary artery disease (CAD).
Methods And Results:
The Japanese CAD (JCAD) study enrolled 15,628 patients who had significant diameter stenosis (>or=75%) in at least 1 coronary artery. Of these, 6,802 patients had their baseline serum CRP data available. Patients were followed up for a mean of 2.7 years (follow-up rate 88.3%). The primary endpoint of the JCAD study was all events. Baseline covariates possibly influencing the event rate were adjusted between the 2 groups with and without elevated serum CRP level. Kaplan-Meier analysis demonstrated a 30% higher all-events rate in patients with a serum level of CRP >or=0.1 mg/dl (P=0.0002). Cox proportional hazard analysis also showed that a serum level of CRP >or=0.1 mg/dl was an independent predictor of all events (P=0.0001), and of cardiac events and cardiac death (P=0.0005).
Conclusions:
Elevated serum level of CRP is an independent predictor of cardiovascular events in JCAD patients.
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