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Taste masking by spray-drying technique.

Divyakumar Bora¹, Priyanka Borude, Kiran Bhise

¹HOD Pharmaceutics, Allana College of Pharmacy, Azam campus, Pune 411001, India.

AAPS Pharmscitech

|November 20, 2008

Summary

This study developed taste-masked microspheres for ondansetron hydrochloride (OSH) using spray-drying. Eudragit and Chitosan polymers effectively masked the bitter taste of OSH, improving drug delivery.

Area of Science:

Pharmaceutical Technology
Drug Delivery Systems
Materials Science

Background:

Ondansetron hydrochloride (OSH) is an intensely bitter drug, posing challenges for patient compliance.
Taste masking is crucial for improving the palatability and administration of bitter medications.
Microsphere technology offers a promising approach for controlled drug release and taste masking.

Purpose of the Study:

To develop taste-masked microspheres of ondansetron hydrochloride (OSH) using spray-drying.
To evaluate the efficacy of different polymers (Chitosan, Methocel E15 LV, Eudragit E100) for taste masking OSH.
To investigate the impact of drug-polymer ratios on taste masking and drug release characteristics.

Main Methods:

Spray-drying technique was employed for microsphere fabrication.

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Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were used for characterization.

In vitro bitter taste evaluation and drug release studies were conducted.

Main Results:

Methocel E15 LV microspheres showed no significant taste masking.
Eudragit E100 microspheres achieved taste masking at a 1:2 drug-polymer ratio.
Chitosan microspheres demonstrated taste masking at a 1:1 drug-polymer ratio.
Eudragit microspheres exhibited rapid drug release (96.85% in 15 min), while Chitosan microspheres showed slower release (40.07% in 15 min).

Conclusions:

Eudragit E100 and Chitosan are effective polymers for taste-masking ondansetron hydrochloride (OSH) via spray-drying.
The drug-polymer ratio significantly influences the taste masking and release profiles of OSH microspheres.
Optimized microsphere formulations can enhance patient compliance by masking the bitter taste of OSH.