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Isolation and confirmation of Yersinia pestis mutants exempt from select agent regulations

Robert D Perry1, Scott W Bearden

  • 1Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, USA.

Current Protocols in Microbiology
|November 20, 2008
PubMed

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Plague01:24

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Plague is a highly virulent zoonotic disease caused by Yersinia pestis, a Gram-negative, facultatively anaerobic coccobacillus. This pathogen primarily circulates among rodent populations and is transmitted to humans through the bite of infected fleas. Additional transmission routes include direct contact with infected animal tissue or inhalation of respiratory droplets from individuals with pneumonic plague. These multiple transmission pathways highlight the bacterium’s potential for rapid...