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Published on: May 19, 2023
Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine
Grit Sommer1, Antje Garten, Stefanie Petzold
1Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany.
Abstract:
Over the last few years, it has become obvious that obesity and insulin resistance are linked by a variety of proteins secreted by adipocytes. Visfatin/PBEF (pre-B-cell colony-enhancing factor) has recently been identified as a novel adipokine with insulin-mimetic effects. Furthermore, an enzymatic function has been reported that reveals visfatin/PBEF as Nampt (nicotinamide phosphoribosyltransferase; EC 2.4.2.12.). Moreover, reports on the structure and hormonal regulation of visfatin/PBEF/Nampt have given further insights into its potential physiological role. The present review summarizes studies on visfatin/PBEF/Nampt as a novel adipokine.
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