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Development and validation of a self-administered Food Allergy Quality of Life Questionnaire for children
B M J Flokstra-de Blok1, A DunnGalvin, B J Vlieg-Boerstra
1Department of Paediatrics, Division of Paediatric Pulmonology and Paediatric Allergy, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. b.m.j.flokstra.de.blok@bkk.umcg.nl
Insights
A new questionnaire, the Food Allergy Quality of Life Questionnaire–Child Form (FAQLQ-CF), effectively measures health-related quality of life in children with food allergies. This validated tool is easy to use and aids in clinical research.
Area of Science:
- Pediatric Allergy and Immunology
- Health-Related Quality of Life (HRQL) Research
- Psychometrics and Questionnaire Development
Background:
- Food allergies significantly impact children's health-related quality of life (HRQL).
- A validated, self-administered, disease-specific HRQL questionnaire for pediatric food allergy was previously unavailable.
- Addressing this gap is crucial for accurate assessment and research in pediatric food allergy.
Purpose of the Study:
- To develop and validate the Food Allergy Quality of Life Questionnaire–Child Form (FAQLQ-CF) in Dutch.
- To create a reliable and disease-specific instrument for assessing HRQL in children with food allergies.
- To provide a tool for use in clinical research and practice.
Main Methods:
- Generated 139 HRQL items through interviews with 13 food-allergic children (aged 8-12).
- Identified key items using the clinical impact method with 51 food-allergic children, resulting in the 24-item FAQLQ-CF.
- Validated the FAQLQ-CF cross-sectionally using 115 food-allergic children, comparing it with the FAIM and CHQ-CF87.
Main Results:
- Demonstrated construct validity through significant correlation between FAQLQ-CF and FAIM (rho=0.60).
- Achieved excellent internal consistency (Cronbach's alpha=0.94) and discriminated based on the number of food allergies.
- Showed convergent/discriminant validity by correlating with 8 of 11 CHQ-CF87 sub-scales.
Conclusions:
- The FAQLQ-CF is the first self-administered, disease-specific HRQL questionnaire for food-allergic children.
- The questionnaire exhibits strong internal consistency and cross-sectional validity.
- The FAQLQ-CF is a potentially valuable tool for clinical research due to its validity, ease of use, and ability to differentiate patient groups.
Background:
Having a food allergy may affect health-related quality of life (HRQL). Currently, no validated, self-administered, disease-specific HRQL questionnaire exists for children with food allergy.
Objective:
The aim of this study was to develop and validate the Food Allergy Quality of Life Questionnaire--Child Form (FAQLQ-CF) in the Dutch language.
Methods:
Interviews with food-allergic children (n=13, 8-12 years) generated 139 HRQL items. The most important items were identified by 51 food-allergic children using the clinical impact method. This resulted in the FAQLQ-CF containing 24 items (total score range 1 'not troubled' to 7 'extremely troubled'). The FAQLQ-CF, the Food Allergy Independent Measure (FAIM) and a generic HRQL questionnaire (CHQ-CF87) were sent to 115 food-allergic children for cross-sectional validation of the FAQLQ-CF.
Results:
Construct validity was demonstrated by the correlation between the FAQLQ-CF and the FAIM (rho=0.60, P<0.001). The FAQLQ-CF had an excellent internal consistency (Cronbach's alpha=0.94) and discriminated between children who differed in number of food allergies (>2 food allergies vs. < or =2 food allergies; total FAQLQ-CF score, 4.3 vs. 3.6; P=0.036), but did not discriminate between reported anaphylaxis or not. The total FAQLQ-CF score correlated with 8 of the 11 CHQ-CF87 sub-scales which demonstrated convergent/discriminant validity.
Conclusion:
The FAQLQ-CF is the first self-administered disease-specific HRQL questionnaire for food-allergic children. This questionnaire has a strong internal consistency and cross-sectional validity. It discriminates between children who differ in number of food allergies, and it was short and easy to use in the population studied. Therefore, the FAQLQ-CF may be a useful tool in clinical research.
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