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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
Published on: April 16, 2019
The danger within: endogenous danger signals, atopy and asthma
1Laboratory of Immunoregulation and Mucosal Immunity, Department of Pulmonary Medicine, Ghent University, Ghent, Belgium. Monique.willart@ugent.be
Summary
Allergic asthma involves airway inflammation triggered by allergens and other factors. Both pattern-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) are crucial for initiating immune responses to allergens.
Area of Science:
- Immunology
- Allergy Research
- Respiratory Medicine
Background:
- Airway inflammation in allergic asthma is initiated by specific or non-specific triggers.
- Dendritic cells (DCs) are key in T helper-2 cell differentiation towards aeroallergens.
- Antigen activation of DCs requires pattern-associated molecular patterns (PAMPs) and endogenous danger signals like damage-associated molecular patterns (DAMPs).
Purpose of the Study:
- To investigate the collaborative role of PAMPs and DAMPs in initiating allergic immune responses.
- To highlight the significance of endogenous danger signals in allergic disease.
- To explore the potential role of these factors in chronic allergic disease and airway remodeling.
Main Methods:
- Review of existing literature on immune responses in allergic asthma.
- Analysis of the interplay between PAMPs and DAMPs in dendritic cell activation.
- Examination of evidence for endogenous danger signals in allergic disease pathogenesis.
Main Results:
- A synergistic interaction between PAMPs and DAMPs is essential for initiating immune responses to allergens.
- Endogenous danger signals play a significant role in the onset and progression of allergic diseases.
- These danger signals contribute to the activation and recruitment of inflammatory cells.
Conclusions:
- The collaboration between PAMPs and DAMPs is critical for initiating allergic inflammation.
- Endogenous danger signals are important in both the initiation and maintenance of allergic diseases.
- Future research should focus on the role of these signals in chronic allergic conditions and airway remodeling.
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