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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Cardiac and great vessel involvement in "Behcet's disease"
Mehrab Marzban1, Mohammad Hossein Mandegar, Abbasali Karimi
1Tehran Heart Center, Medical Sciences, University of Tehran, Tehran, Iran. mehrabmarzban2007@yahoo.com
Journal of Cardiac Surgery
|November 20, 2008
Summary
Behcet's disease, a rare vasculitic syndrome, can affect the heart and great vessels. This review highlights its diverse cardiovascular manifestations and presents four unique cases for cardiac surgeons.
Area of Science:
- Cardiovascular Medicine
- Rheumatology
- Vascular Surgery
Background:
- Behcet's disease is a rare multisystemic inflammatory disorder.
- It is characterized by vasculitis affecting various organ systems.
- Cardiac and great vessel involvement, though uncommon, presents significant risks.
Observation:
- Cardiac manifestations include pericarditis, cardiomyopathy, endocarditis, and coronary artery disease.
- Great vessel involvement is more frequent, presenting as phlebitis or arterial aneurysms/pseudoaneurysms.
- Specific cases reviewed involve aneurysms of the ascending aorta, descending aorta, pulmonary artery, and pseudoaneurysm of the aortic arch.
Findings:
- Cardiovascular involvement in Behcet's disease is diverse, ranging from endocardial to great vessel pathologies.
- Arterial involvement commonly manifests as aneurysms or pseudoaneurysms.
- Venous involvement, such as recurrent phlebitis, is also a notable presentation.
Implications:
- Familiarity with Behcet's disease's cardiovascular spectrum is crucial for cardiac surgeons due to high mortality.
- Early recognition and management of vascular complications are essential.
- This review underscores the need for a multidisciplinary approach in managing patients with Behcet's disease and cardiovascular complications.
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