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Published on: September 12, 2019
Myxomatous neoplasms in the perineal region of baboons
Shannon M Wallace1, Kathleen A Szabo, Natalia E Schlabritz-Loutsevitch
1Department of Pathology, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA. shannon.m.wallace@us.army.mil
Background:
In baboons, Papio sp. neoplasms tend to affect the hematopoietic system most commonly, with rare documentation of myxomatous neoplasms. In contrast, women can develop myxomatous masses within deep peripelvic tissues with some frequency during their reproductive years.
Methods:
We have identified and examined, retrospectively, myxomatous perineal masses in twelve female baboons within one research facility and compared their histopathologic, immunohistochemical and electron microscopic features to their human variants.
Results:
Our results indicate that these myxomatous neoplasms, in humans and non-human primates, share common features.
Conclusion:
Further research, particularly molecular genetic analysis, may be needed to identify the baboon as a true animal model for myxomatous perineal neoplasms.
