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Published on: March 26, 2019
Rasmussen's encephalitis and Behcet's disease: autoimmune disorders in first degree relatives
Demet Kinay1, Nerses Bebek, Ebru Vanli
1Bakirkoy State Hospital for Research and Training in Neurology, Neurosurgery, and Psychiatry, Istanbul. demet.kinay@gmail.com
Abstract:
We report a patient with adolescent-onset, Rasmussen's encephalitis, presenting with intractable focal seizures, mild hemiparesis, cognitive impairment, dystonia, and severe hemiballism. His father had Behcet's disease, considered to be an autoimmune disorder. Recent reports have directly implicated the role of cytotoxic T lymphocytes in the pathogenesis of both Rasmussen's encephalitis and Behcet's disease. The occurrence of Behcet's disease and Rasmussen's encephalitis in the same family suggests involvement of common genetic factors such as HLA haplotypes in both autoimmune disorders. It is possible that members of this family are genetically susceptible to developing autoimmune conditions that have been precipitated by separate environmental triggers.
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