Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Lipid Absorption01:24

Lipid Absorption

Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety Assessment of <i>Melaleuca alternifolia</i> (Tea Tree)-Derived Ingredients as Used in Cosmetics.

International journal of toxicology·2026
Same author

Safety Assessment of Radish Root - Derived Ingredients as Used in Cosmetics.

International journal of toxicology·2026
Same author

RNASET2 degrades mRNAs that protect against lipotoxicity.

Molecular metabolism·2026
Same author

Intestinal fructose metabolism drives unsaturated fat absorption and synergizes with GLP-1 receptor agonism to promote weight loss.

bioRxiv : the preprint server for biology·2026
Same author

Amended Safety Assessment of Naturally-Sourced Clays as Used in Cosmetics.

International journal of toxicology·2026
Same author

Allergic contact dermatitis to personal care products: A focus on established and emerging allergens.

Journal of the American Academy of Dermatology·2026

Related Experiment Video

Updated: Jun 27, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Biliary lipids and cholesterol gallstone disease.

David Q-H Wang1, David E Cohen, Martin C Carey

  • 1Department of Medicine, Harvard Medical School, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, and Harvard Digestive Diseases Center, and Brigham and Women's Hospital, Boston, MA 02115, USA.

Journal of Lipid Research
|November 20, 2008
PubMed
Summary

Cholesterol gallstone formation involves biliary lipid imbalances, gallbladder dysfunction, and genetic factors. Understanding these elements is key to addressing this common condition.

Related Experiment Videos

Last Updated: Jun 27, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

  • Biliary lipid metabolism and gallstone pathogenesis.

Background:

  • Biliary lipids include bile salts, phospholipids, cholesterol, and bilirubin conjugates.
  • Cholesterol gallstone disease is primarily linked to excessive hepatic cholesterol secretion into bile.

Purpose of the Study:

  • To review current understanding of biliary lipid physical-chemical states in health and disease.
  • To outline factors contributing to cholesterol gallstone pathogenesis.

Main Methods:

  • Review of current concepts in biliary lipid science.
  • Analysis of molecular, genetic, hepatic, and cholecystic factors.

Main Results:

  • Gallbladder abnormalities like hypomotility and mucin hypersecretion contribute to gallstone formation.
  • Genetic factors (LITH genes), metabolic syndrome, insulin resistance, and environmental factors interact to cause gallstones.

Conclusions:

  • Cholesterol nucleation occurs via fusion of lipid vesicles, forming crystals that aggregate with mucin gel.
  • Understanding the complex interplay of factors is crucial for managing cholesterol gallstones.