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Cutting edge: viral infection breaks NK cell tolerance to "missing self"

Joseph C Sun1, Lewis L Lanier

  • 1Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|November 20, 2008
PubMed
Summary

Natural killer (NK) cells normally tolerate cells lacking MHC class I. However, infection can break this tolerance, leading to NK cell rejection of these "missing self" cells.

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