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Updated: Jul 4, 2026

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PCTA: a new player in TGF-beta signaling

Fang Liu1

  • 1Center for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey, 679 Hoes Lane, Piscataway, NJ 08854, USA. fangliu@cabm.rutgers.edu

Science Signaling
|November 20, 2008
PubMed
Summary

PCTA promotes TGF-beta signaling by competing with TGIF, freeing cytoplasmic PML. This interaction enhances Smad2/3 phosphorylation, driving TGF-beta-mediated growth inhibition and transcriptional regulation.

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