Related Experiment Videos

Paecilomyces lilacinus peritonitis complicating peritoneal dialysis cured by oral voriconazole and terbinafine

Brian Pin-Hsuan Chang1, Pei-Lun Sun2, Fu-Yuan Huang3,1

  • 1Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.

Journal of Medical Microbiology
|November 20, 2008
PubMed

Insights

Fungal peritonitis (FP) is a serious complication for patients on continuous ambulatory peritoneal dialysis (CAPD). A rare Paecilomyces lilacinus infection was successfully treated with oral voriconazole and terbinafine.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Mycology

Background:

  • Fungal peritonitis (FP) is a severe complication in patients undergoing continuous ambulatory peritoneal dialysis (CAPD).
  • Paecilomyces lilacinus is a rare fungal pathogen causing peritonitis in CAPD patients.
  • Uraemic patients on CAPD are susceptible to serious infectious complications.

Observation:

  • A 15-year-old boy with uraemia on CAPD developed fungal peritonitis.
  • The causative agent was identified as Paecilomyces lilacinus.
  • The patient presented with symptoms indicative of peritonitis.

Findings:

  • Successful treatment of CAPD-related Paecilomyces lilacinus peritonitis was achieved.
  • Combination therapy with oral voriconazole and terbinafine was employed.
  • This therapeutic regimen has not been previously reported for fungal peritonitis.

Implications:

  • This case highlights a novel and effective treatment strategy for a rare fungal peritonitis.
  • Voriconazole and terbinafine combination therapy may be a viable option for managing Paecilomyces lilacinus infections in CAPD patients.
  • Further research is warranted to establish the efficacy and safety of this treatment in a larger cohort.

Related Concept Videos

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Peritoneal Dialysis I: Introduction and Procedure01:30

Peritoneal Dialysis I: Introduction and Procedure

Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...