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Persistent Candida parapsilosis funguria associated with an indwelling urinary tract stent for more than 7 years

Sheng-Yuan Ruan1, Jung-Yien Chien1, Po-Ren Hsueh2

  • 1Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan, ROC.

Journal of Medical Microbiology
|November 20, 2008
PubMed

Insights

Persistent Candida parapsilosis funguria, often linked to urinary tract instrumentation, presents treatment challenges. Despite prolonged therapy and catheter changes, eradication was not achieved, highlighting the need for novel antifungal strategies.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Urology

Background:

  • Candiduria, a fungal infection in urine, is rising.
  • Effective antifungal treatments are limited, causing concern.
  • Urinary tract instrumentation is a common risk factor.

Observation:

  • A persistent case of Candida parapsilosis funguria was observed.
  • The infection was associated with urinary tract instrumentation.
  • Molecular typing confirmed a single strain persisting over 7 years.

Findings:

  • Prolonged antifungal therapy and catheter replacement did not eradicate the funguria.
  • Urinary symptoms and pyuria showed improvement.
  • Antifungal susceptibility remained unchanged despite fluconazole exposure.

Implications:

  • This case underscores the difficulty in treating persistent candiduria.
  • The study highlights the need for advanced treatment strategies for resistant fungal infections.
  • Understanding strain persistence is crucial for managing recurrent urinary tract infections.

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