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The human aldose reductase gene maps to chromosome region 7q35
A Graham1, P Heath, J E Morten
1Biotechnology Department, ICI Pharmaceuticals, Alderley Park, Macclesfield, UK.
Human Genetics
|March 1, 1991
Abstract:
The human aldose reductase (AR) gene has been mapped to chromosome 7 using the polymerase chain reaction to specifically amplify the human AR sequence in hamster/human hybrid DNA and also in mouse/human monochromosome hybrids. The assignment to chromosome 7 was confirmed by in situ hybridisation to human metaphase chromosomes using a novel, rapid hybridisation, method giving a regional localisation at 7q35.