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Updated: Jun 27, 2026

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
10:02

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)

Published on: March 12, 2020

Reduced serotonergic functioning changes heart rate in ADHD.

Florian Daniel Zepf1, M Holtmann, C Stadler

  • 1Department of Child and Adolescent Psychiatry and Psychotherapy, Goethe University of Frankfurt am Main, Deutschordenstr, Frankfurt, Germany. F.Zepf@med.uni-frankfurt.de

Journal of Neural Transmission (Vienna, Austria : 1996)
|November 20, 2008
PubMed
Summary
This summary is machine-generated.

Reduced heart rate (HR) in boys with ADHD may indicate aggression linked to serotonin. This study explored the connection between serotonin function, HR, and aggressive behavior in adolescents with ADHD.

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Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
10:02

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)

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Using Brain Activation (nir-HEG/Q-EEG) and Execution Measures (CPTs) in a ADHD Assessment Protocol
13:09

Using Brain Activation (nir-HEG/Q-EEG) and Execution Measures (CPTs) in a ADHD Assessment Protocol

Published on: April 1, 2018

Area of Science:

  • Neuroscience
  • Psychiatry
  • Human Physiology

Background:

  • Reduced mean heart rate (HR) is a biophysiological marker for aggression.
  • Aggression is linked to altered serotonergic neurotransmission.
  • Understanding these links is crucial for ADHD management.

Purpose of the Study:

  • To investigate the relationship between serotonin function, heart rate, and aggressive behavior in boys diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD).
  • To assess if acute tryptophan depletion (a method to temporarily reduce serotonin levels) affects heart rate and aggression in ADHD patients.

Main Methods:

  • A double-blind, within-subject crossover study involving 16 boys diagnosed with ADHD.
  • Participants underwent two conditions: rapid tryptophan depletion (RTD) and a placebo.
  • Mean heart rate (HR) was measured under both RTD and placebo conditions.

Main Results:

  • Boys with ADHD who displayed aggressive behavior under RTD showed a significantly lowered HR compared to the placebo condition.
  • Diminished serotonin (5-HT) functioning was associated with both a lowered HR and increased aggressive behavior.
  • These findings suggest a link between reduced serotonin and aggressive tendencies in this population.

Conclusions:

  • Reduced serotonin function is associated with lowered heart rate and aggressive behavior in ADHD patients.
  • Mean heart rate may serve as a biophysiological marker for aggression in the context of altered serotonergic neurotransmission.
  • Further research into serotonin modulation could offer new therapeutic avenues for aggression in ADHD.