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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Evidence-based medicine beyond the bedside: keeping an eye on context
1Mayo Clinic, Rochester, MN, USA. tilburt.jon@mayo.edu
Journal of Evaluation in Clinical Practice
|November 21, 2008
Summary
Evidence-based decision-making extends beyond patient care, incorporating research evidence, social context, and stakeholder values. Expert judgment is crucial for integrating these elements effectively in diverse settings.
Area of Science:
- Decision Sciences
- Public Health
- Health Policy
Background:
- Evidence-based medicine (EBM) principles are increasingly applied beyond direct patient care.
- Disagreement exists on defining EBM components in institutional and public health contexts.
Purpose of the Study:
- Review key elements of EBM in clinical medicine.
- Adapt EBM elements for broader application in institutional, public health, and self-care decision-making.
Main Methods:
- Conceptual analysis of evidence-based decision-making frameworks.
- Identification of core components and their integration.
Main Results:
- Evidence-based decision-making integrates research evidence, social/institutional circumstances, and stakeholder values.
- Expert judgment is essential for weighing and integrating these diverse elements.
Conclusions:
- Evidence-based reasoning principles are applicable beyond clinical settings.
- Critical questioning regarding decision purpose and context enables broader EBM application.
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