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Double Inversion Recovery MRI with fat suppression at 7 tesla: initial experience

Guillaume Madelin1, Niels Oesingmann, Matilde Inglese

  • 1Department of Radiology, New York University, New York, NY, USA.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|November 21, 2008
PubMed
Abstract

Insights

Double Inversion Recovery (DIR) Magnetic Resonance Imaging is feasible at 7 Tesla for in vivo brain imaging. This advanced MRI technique enables clear delineation of gray matter by suppressing white matter and CSF signals.

Area of Science:

  • Medical Imaging
  • Neuroimaging
  • Magnetic Resonance Imaging

Background:

  • Double Inversion Recovery (DIR) Magnetic Resonance Imaging (MRI) suppresses signals from tissues with different T1 relaxation times.
  • DIR-MRI is used in the brain to image gray matter (GM) by nulling white matter (WM) and cerebrospinal fluid (CSF) signals.
  • Low signal-to-noise ratio (SNR) is a limitation of DIR, but high-field 7 Tesla (7T) magnets offer potential for higher SNR.

Purpose of the Study:

  • To demonstrate the feasibility of in vivo brain Double Inversion Recovery Magnetic Resonance Imaging (DIR-MRI) at 7 Tesla.
  • To evaluate fat suppression techniques for DIR-MRI at 7T and 3T.

Main Methods:

  • MRI experiments were conducted on phantoms and four healthy volunteers at 7T and 3T.
  • A chemical shift selective Fat Inversion Recovery (csFatIR) technique was used for fat suppression and compared to standard fat saturation (FatSat).

Main Results:

  • The csFatIR method demonstrated significantly higher efficiency than FatSat at 7T.
  • csFatIR was also slightly more efficient than FatSat at 3T.
  • Both methods enabled clear delineation of gray matter.

Conclusions:

  • Double Inversion Recovery (DIR) Magnetic Resonance Imaging (MRI) is feasible at 7 Tesla for in vivo brain imaging.
  • DIR-MRI at 7T is achievable despite challenges with B1 in-homogeneity.
  • The study highlights the potential of 7T MRI for improved neuroimaging.

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