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Related Experiment Video

Updated: Jun 27, 2026

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Published on: April 26, 2019

Hirschsprung disease.

Ramanath N Haricharan¹, Keith E Georgeson

¹Division of Pediatric Surgery, Department of General Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.

Seminars in Pediatric Surgery

|November 21, 2008

Summary

Hirschsprung disease management has advanced significantly, with minimally invasive surgery now a popular option for neonates. These modern strategies reduce patient morbidity and improve surgical outcomes.

Area of Science:

Pediatric surgery
Gastroenterology
Genetics

Background:

Hirschsprung disease is a common congenital disorder affecting the large intestine.
Recent decades have seen major progress in understanding its genetic causes.
Surgical approaches have evolved from multi-stage to primary operations.

Purpose of the Study:

To review the advancements in Hirschsprung disease management.
To highlight the impact of molecular genetics and minimally invasive surgery.
To discuss improved outcomes in neonates.

Main Methods:

Review of recent literature on Hirschsprung disease.
Analysis of evolving surgical techniques.
Examination of genetic and diagnostic advancements.

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A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

Published on: September 18, 2013

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Last Updated: Jun 27, 2026

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5

Published on: April 26, 2019

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

Published on: September 18, 2013

Main Results:

Molecular genetics has enhanced understanding of Hirschsprung disease etiologies.
Minimally invasive surgical techniques are increasingly adopted for definitive treatment.
Neonatal surgical strategies now focus on reduced morbidity and better outcomes.

Conclusions:

Surgical management of Hirschsprung disease has progressed to primary, minimally invasive procedures.
Advancements in genetics and surgical techniques have led to improved outcomes for neonates.
Continued innovation promises further reductions in patient morbidity.