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Related Experiment Video

Updated: Jun 27, 2026

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells

Published on: November 12, 2015

Insights into adenovirus host cell interactions from structural studies.

G R Nemerow¹, L Pache, V Reddy

¹The Scripps Research Institute, La Jolla, California, 92037, USA. gnemerow@scripps.edu

|November 21, 2008

Summary

Human adenoviruses cause infections but are vital models for cell biology. Structure-based methods reveal molecular details of adenovirus-host interactions, aiding gene therapy and vaccine development.

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Adenofection: A Method for Studying the Role of Molecular Chaperones in Cellular Morphodynamics by Depletion-Rescue Experiments

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Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells

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Adenofection: A Method for Studying the Role of Molecular Chaperones in Cellular Morphodynamics by Depletion-Rescue Experiments

Adenofection: A Method for Studying the Role of Molecular Chaperones in Cellular Morphodynamics by Depletion-Rescue Experiments

Published on: September 16, 2016

Area of Science:

Virology
Structural Biology
Molecular Biology

Background:

Human adenoviruses are significant causes of respiratory, enteric, and ocular infections.
Adenoviruses serve as crucial model systems in cell and molecular biology research.
Replication-defective adenoviruses are utilized in gene transfer and vaccine clinical trials.

Purpose of the Study:

To review the application of structure-based approaches in understanding adenovirus-host interactions.
To highlight recent insights into the adenovirus life cycle and immune system interactions.

Main Methods:

Utilizing advances in structural biology techniques.
Analyzing molecular features of adenovirus-host interactions.
Reviewing structure-based studies on adenovirus biology.

Main Results:

Structural biology has provided key insights into early adenovirus life cycle events.
Understanding of virus interactions with host immune system components has advanced.
Molecular details of adenovirus-host interactions are being uncovered through structure-based methods.

Conclusions:

Structure-based approaches continue to be instrumental in elucidating adenovirus biology.
These methods are crucial for understanding adenovirus pathogenesis and developing therapeutic applications.
Continued research using these techniques will further advance knowledge of adenovirus-host interactions.