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C-mip interacts physically with RelA and inhibits nuclear factor kappa B activity.

Maud Kamal1, Asta Valanciute, Karine Dahan

  • 1INSERM, U 841, Créteil 94010, France; Institut Mondor de Recherche Biomédicale (IMRB), Département "génétique", Equipe "21", Créteil, F-94010, France.

Molecular Immunology
|November 21, 2008
PubMed
Summary

The novel protein c-mip regulates nuclear factor-kappa B (NF-kappaB) activity by inhibiting GSKbeta and stabilizing NF-kappaB/I-kappaBalpha complexes. This finding reveals c-mip as a key regulator in the NF-kappaB signaling pathway.

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