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11:17
Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
Isolated growth hormone deficiency: clinical entity?
A Bianchi1, A Giampietro, A Pontecorvi
1Department of Endocrinology, Catholic University, School of Medicine, 00168 Rome, Italy. abianchi69@yahoo.it
Journal of Endocrinological Investigation
|December 17, 2008
Summary
Isolated Growth Hormone Deficiency (IGHD) is diagnosed through clinical assessment and biochemical tests. Therapeutic response to GH replacement is favorable, especially in severe cases of IGHD.
Area of Science:
- Endocrinology
- Pediatric Endocrinology
- Genetics
Background:
- Isolated Growth Hormone Deficiency (IGHD) is defined as growth hormone deficiency (GHD) without other pituitary hormone deficiencies.
- IGHD can be associated with or without organic lesions and presents differently based on age of onset.
Purpose of the Study:
- To outline the diagnostic criteria and classifications of IGHD in both childhood and adulthood.
- To discuss the therapeutic response to growth hormone (GH) replacement in IGHD patients.
Main Methods:
- Clinical and auxological assessment in children.
- Biochemical tests, including GH provocative tests and IGF-I levels in adults.
- Neuroradiological and genetic evaluations for diagnosis.
Main Results:
- Childhood IGHD categorizes into organic, genetic, and idiopathic types.
- Adult IGHD includes prior childhood IGHD, acquired secondary to lesions/trauma, and idiopathic.
- Diagnosis in adults requires positive GH provocative tests and low IGF-I levels.
- Therapeutic response to GH replacement is favorable in both adult and childhood-onset IGHD, particularly in severe cases.
Conclusions:
- IGHD diagnosis requires a comprehensive approach combining clinical, biochemical, and imaging data.
- GH replacement therapy is effective for IGHD, with the best outcomes in patients with more severe deficiency.
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