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Updated: Jun 27, 2026

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
Published on: November 22, 2014
Chemical analogues relevant to molybdenum and tungsten enzyme reaction centres toward structural dynamics and
Hideki Sugimoto1, Hiroshi Tsukube
1Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka, 558-8585, Japan. sugimoto@sci.osaka-cu.ac.jp
Abstract:
Recent characterisation of molybdenum and tungsten enzymes revealed novel structural types of reaction centres, as well as providing new subjects of interest as synthetic chemical analogues. This tutorial review highlights the structure/reactivity relationships of the enzyme reaction centres and chemical analogues. Chemical analogues for the oxygen atom transfer enzymes have been well expanded in structure and reactivity. Other types of chemical analogues that exhibit different coordination chemistry have recently been presented for reaction centres of the hydroxylation and dehydrogenation enzymes and others.
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