Peptides and peptide mimics as modulators of apoptotic pathways

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Updated: Jun 27, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

Mar Orzáez1, Anna Gortat, Laura Mondragón

  • 1Department of Medicinal Chemistry, Centro de Investigación Príncipe Felipe, Valencia, Spain.

Chemmedchem
|November 21, 2008
PubMed

Insights

Programmed cell death, or apoptosis, is crucial for health. Modulating apoptosis with peptides offers a promising therapeutic strategy for diseases like cancer and neurodegeneration.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Drug Discovery

Background:

  • Programmed cell death (apoptosis) is a fundamental biological process essential for development and tissue homeostasis.
  • Dysregulation of apoptosis is implicated in numerous diseases, including cancer, neurodegenerative disorders, autoimmune diseases, and conditions involving excessive cell loss.
  • Identifying therapeutic targets within apoptotic pathways is a significant focus in biomedical research.

Purpose of the Study:

  • To highlight the critical role of apoptosis in health and disease.
  • To explore the potential of targeting apoptotic pathways for therapeutic intervention.
  • To emphasize the utility of peptides in drug development for modulating apoptosis.

Main Methods:

  • Review of existing literature on programmed cell death and its regulation.
  • Analysis of disease mechanisms linked to apoptotic pathway dysfunction.
  • Evaluation of peptides as therapeutic agents for controlling apoptosis.

Main Results:

  • Aberrant apoptosis underlies various pathologies, from cancer to neurodegeneration.
  • Targeting apoptotic pathways presents a viable strategy for disease treatment.
  • Peptides are effective tools for modulating apoptosis in drug discovery and development.

Conclusions:

  • Controlling programmed cell death is vital for preventing and treating a spectrum of diseases.
  • Peptide-based therapeutics hold significant promise for future drug development in apoptosis-related disorders.

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