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Macromolecular diffusion in the extracellular matrix measured by fluorescence correlation spectroscopy

Nina Kristine Reitan1, Aphirak Juthajan, Tore Lindmo

  • 1The Norwegian University of Science and Technology, Department of Physics, 7491 Trondheim, Norway. nina.reitan@ntnu.no

Journal of Biomedical Optics
|November 22, 2008
PubMed
Summary

Fluorescence correlation spectroscopy (FCS) effectively measures macromolecule diffusion in tumor models, revealing complex transport behaviors not seen with fluorescence recovery after photobleaching (FRAP). This highlights FCS for extracellular drug delivery research.

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