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Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Chapter 10. Methods for evaluating uteroplacental angiogenesis and their application using animal models
Pawel P Borowicz1, Shireen Hafez, Dale A Redmer
1Center for Nutrition and Pregnancy, and Department of Animal Sciences, North Dakota State University, Fargo, North Dakota, USA.
Methods in Enzymology
|November 22, 2008
Summary
Placental angiogenesis is crucial for fetal development. This study explores methods to evaluate placental microcirculation and its role in both normal and compromised pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Developmental Biology
- Vascular Biology
Background:
- Placental angiogenesis is vital for fetal growth.
- Understanding placental microcirculation is key in normal and compromised pregnancies.
Purpose of the Study:
- To present evidence on the importance of placental angiogenesis.
- To describe methodologies for evaluating placental microcirculation.
- To discuss changes in placental angiogenesis in pregnancy models.
Main Methods:
- Sampling techniques for placental microcirculation.
- Computerized analysis and reconstruction of placental microvasculature.
- Evaluation of placental function.
Main Results:
- Evidence supporting the critical role of placental angiogenesis.
- Detailed methodologies for assessing placental microcirculation.
- Observed changes in placental angiogenesis in various pregnancy models.
Conclusions:
- Placental angiogenesis is essential for fetal development.
- Methodologies for its evaluation are established.
- Further research is needed to address remaining questions.
