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Updated: Jun 27, 2026
Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Chapter 10. Methods for evaluating uteroplacental angiogenesis and their application using animal models
Pawel P Borowicz1, Shireen Hafez, Dale A Redmer
1Center for Nutrition and Pregnancy, and Department of Animal Sciences, North Dakota State University, Fargo, North Dakota, USA.
In this chapter, we present some of the compelling evidence confirming the importance of placental angiogenesis to fetal growth and development in normal and compromised pregnancies. We then describe the methodology that has been used to evaluate placental angiogenesis throughout pregnancy, including both the practical methods used to obtain reliable samples of the placental microcirculation as well as computerized methods used to analyze and reconstruct it. We then briefly describe the changes in placental angiogenesis and function in the models of normal and compromised pregnancy that we have used, and conclude with what we have learned from these studies and what we believe are the larger questions remaining.
In this chapter, we present some of the compelling evidence confirming the importance of placental angiogenesis to fetal growth and development in normal and compromised pregnancies. We then describe the methodology that has been used to evaluate placental angiogenesis throughout pregnancy, including both the practical methods used to obtain reliable samples of the placental microcirculation as well as computerized methods used to analyze and reconstruct it. We then briefly describe the changes in placental angiogenesis and function in the models of normal and compromised pregnancy that we have used, and conclude with what we have learned from these studies and what we believe are the larger questions remaining.
