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Related Concept Videos

Capillaries and Their Types01:20

Capillaries and Their Types

Capillaries, a crucial constituent of the circulatory system, are diminutive vessels with a diameter between 5–10 micrometers, accommodating perfusion to the tissues through the phenomenon known as microcirculation. Through their permeable walls, consisting of an endothelial layer ensconced by a basement membrane and sporadically dispersed smooth muscle fibers, the exchange of substances between the blood and the interstitial fluid becomes plausible. Variance in wall composition exists, with...
Capillary Beds01:20

Capillary Beds

Capillary beds are networks of tiny blood vessels that play a crucial role in the circulatory system. These beds are where the exchange of gases, nutrients, and waste products occurs between the blood and surrounding tissues. Each capillary bed consists of numerous capillaries, which are the smallest blood vessels in the body, typically only one cell-thick. This thinness allows for the efficient diffusion of substances.
Capillaries connect arterioles, small branches of arteries, to venules,...
Capillarity in Fluid01:19

Capillarity in Fluid

Capillarity describes the movement of liquid in small spaces without external forces acting on it. The capillarity is driven by surface tension and adhesive interactions between the liquid and surrounding solid surfaces. This effect is often seen in narrow tubes, porous materials, and fine particles.
Surface tension is crucial to capillarity. It results from cohesive forces between liquid molecules at the liquid-air boundary, forming a skin that resists external forces. When the capillary tube...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Capillary Exchange01:28

Capillary Exchange

The cardiovascular system's chief role is to disseminate gases, nutrients, waste, and other substances to the body's cells. Small molecules like gases, lipids, and lipid-soluble substances directly diffuse through capillary wall endothelial cell membranes. Glucose, amino acids, and ions, including sodium, potassium, calcium, and chloride, use transporters for facilitated diffusion via membrane-specific channels. Glucose, ions, and bigger molecules may also pass through intercellular clefts.
Rise of Liquid in a Capillary Tube01:18

Rise of Liquid in a Capillary Tube

When very thin cylindrical tubes, called capillaries, are dipped in a liquid, the liquid rises or falls in the tube compared to the surrounding liquid. This phenomenon is called capillary action. Capillary action occurs due to the combination of two opposing forces: the cohesive forces of the liquid, which cause it to stick to itself and form a rounded shape, and the adhesive forces between the liquid and the walls of the container, which cause the liquid to be attracted to the container walls.

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A Patient-Derived Xenograft Model for Venous Malformation
06:51

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Published on: June 15, 2020

What is a capillary malformation?

Rudolf Happle1

  • 1Department of Dermatology, Philipp University of Marburg, Marburg, Germany. happle@med.uni-marburg.de

Journal of the American Academy of Dermatology
|November 22, 2008
PubMed
Summary
This summary is machine-generated.

The term "capillary malformation" is inaccurately used for specific skin conditions like port-wine stains. Researchers propose using "capillary malformation" as a broad category, not a singular diagnosis.

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Area of Science:

  • Dermatology
  • Medical Terminology
  • Vascular Lesions

Background:

  • The term "capillary malformation" is increasingly used to refer to various skin conditions, including nevus flammeus (port-wine stain).
  • Current usage is problematic as it encompasses diverse dermatological entities.
  • This broad application leads to diagnostic ambiguity and potential misclassification of vascular lesions.

Purpose of the Study:

  • To analyze the accuracy and ambiguity of the term "capillary malformation" in current dermatological literature.
  • To advocate for a revised classification of skin lesions currently grouped under "capillary malformation."
  • To propose a more precise nomenclature for vascular skin anomalies.

Main Methods:

  • Review of existing medical literature and classification systems for cutaneous vascular lesions.
  • Analysis of diagnostic criteria for conditions historically and currently labeled as "capillary malformations."
  • Comparison of clinical presentations and pathological features of diverse skin disorders.

Main Results:

  • At least nine distinct skin disorders meet the criteria for "capillary malformation."
  • Examples include nevus anemicus, cutis marmorata telangiectatica congenita, and angiokeratoma circumscriptum.
  • Some lesions, like salmon patches and Rendu-Osler disease manifestations, are miscategorized under this term.

Conclusions:

  • The current designation "capillary malformation" is imprecise and encompasses a wide array of unrelated skin conditions.
  • "Capillary malformation" should be adopted as an umbrella term for a group of vascular anomalies, not as a specific diagnosis.
  • Revising the terminology is crucial for accurate diagnosis, effective treatment, and clear communication in dermatology.