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Related Concept Videos

Methods for Controlling Microbial Growth01:29

Methods for Controlling Microbial Growth

Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
Physical Methods for Controlling Microbial Growth: Radiation and Filtration01:26

Physical Methods for Controlling Microbial Growth: Radiation and Filtration

Radiation and filtration are essential tools for microbial control, targeting microorganisms through distinct mechanisms. Radiation eliminates microbes by damaging their DNA, either killing them or inhibiting their growth. Based on wavelength, radiation is classified into two types: nonionizing and ionizing radiation.Non-ionizing radiation, such as UV radiation (200–400 nm), is absorbed by DNA, causing defects that effectively disinfect surfaces, air, and water, including safety cabinets.
Key Techniques in Microbiology01:19

Key Techniques in Microbiology

Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...

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Updated: Jun 27, 2026

Accessible Silicone Chip-to-Membrane Sealing Procedure for Flexible, Reliable Bonding
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Accessible Silicone Chip-to-Membrane Sealing Procedure for Flexible, Reliable Bonding

Published on: March 20, 2026

Microbial sealing: a new approach to reducing contamination.

S E Wilson1

  • 1University of California, Irvine, CA, USA. wilsonse@uci.edu

The Journal of Hospital Infection
|November 22, 2008
PubMed
Summary

A new microbial sealant significantly reduces surgical wound bacterial contamination. This innovative approach, when used with povidone iodine, offers a valuable strategy for preventing surgical site infections (SSIs).

Area of Science:

  • Surgical Infection Prevention
  • Medical Device Technology
  • Microbiology

Background:

  • Surgical site infections (SSIs) are often caused by endogenous flora.
  • Complete skin sterilization is not achievable with current methods.
  • Preventing bacterial contamination is crucial for reducing SSIs.

Purpose of the Study:

  • To evaluate the efficacy of a cyanoacrylate-based microbial sealant in reducing surgical wound contamination.
  • To compare the sealant's performance against traditional methods like povidone iodine and antimicrobial drapes.

Main Methods:

  • In vitro studies assessed pathogen reduction.
  • In vivo studies compared wound contamination with the sealant versus antimicrobial drapes.
  • A clinical study in 177 patients evaluated wound contamination with the sealant plus povidone iodine versus povidone iodine alone.

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The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
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The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage

Published on: November 4, 2010

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Accessible Silicone Chip-to-Membrane Sealing Procedure for Flexible, Reliable Bonding
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Published on: March 20, 2026

Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
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The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
07:51

The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage

Published on: November 4, 2010

Main Results:

  • In vitro tests showed up to 99.9% reduction in common SSI pathogens.
  • The microbial sealant demonstrated lower wound contamination incidence compared to antimicrobial drapes in vivo.
  • Clinical study: 53.0% wound contamination with sealant + povidone iodine vs. 68.7% with povidone iodine alone.

Conclusions:

  • InteguSeal(*) Microbial Sealant significantly reduces surgical wound bacterial contamination when used with 10% povidone iodine.
  • The sealant mechanically blocks pathogen migration and enhances povidone iodine efficacy.
  • The sealant is easy to apply, safe, and compatible with various surgical techniques, offering a valuable tool for SSI prevention.