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Updated: Jun 27, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
Genetics of susceptibility to malaria related phenotypes
Danielle Carpenter1, Ingegerd Rooth, Anna Färnert
1Faculty of Biological Sciences, Institute of Integrative and Comparative Biology, University of Leeds, Leeds, UK. danielle.carpenter@nottingham.ac.uk
Abstract:
Previous studies have established a genetic component for susceptibility to malaria. Here we use a pedigree based approach, and transmission disequilibrium testing (TDT), to identify immune response genes that influence susceptibility to Plasmodium falciparum malarial phenotypes (parasite density and frequency of clinical episodes) in a Tanzanian population. Evidence for association was observed between markers in the TNF gene cluster and both the malarial phenotypes. There was weaker evidence for associations between HLA-DRB1*04, HLA-DRB1*10, and loci in the TCRBV region with parasite density. There was no evidence for association with polymorphisms in the IL10 promoter, IL1 gene cluster, or from the IL4/IL13 region.
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