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Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Related Experiment Video

Updated: Jun 27, 2026

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
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PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

Biodegradable nanoparticles made from polylactide-grafted dextran copolymers.

C Nouvel1, J Raynaud, E Marie

  • 1Laboratoire de Chimie Physique Macromoléculaire, UMR 7568, CNRS-Nancy-University, ENSIC, BP 20451, 54001 Nancy cedex, France.

Journal of Colloid and Interface Science
|November 22, 2008
PubMed
Summary
This summary is machine-generated.

Biodegradable polyester nanoparticles coated with polysaccharide (dextran) were created using emulsion/solvent evaporation. Their characteristics and stability depend on polylactide-grafted dextran copolymer structure, enabling controlled drug delivery applications.

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Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
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Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

Published on: January 22, 2015

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Polyester nanoparticles are widely investigated for drug delivery due to their biocompatibility and biodegradability.
  • Controlling nanoparticle surface properties is crucial for enhancing colloidal stability and targeted delivery.
  • Dextran, a polysaccharide, offers excellent biocompatibility and hydrophilicity, making it suitable for nanoparticle surface modification.

Purpose of the Study:

  • To prepare and characterize polysaccharide-covered polyester nanoparticles using a novel emulsion/solvent evaporation method.
  • To investigate the correlation between the structural parameters of polylactide-grafted dextran copolymers and nanoparticle characteristics.
  • To evaluate the biodegradability of the developed nanoparticles for potential biomedical applications.

Main Methods:

  • Nanoparticles were synthesized via emulsion/solvent evaporation using polylactide (PLA) or PLA/copolymer blends as the core material.
  • Polylactide-grafted dextran copolymers were employed as stabilizers to achieve dextran surface coverage.
  • Nanoparticle characterization included size, surface coverage, superficial layer thickness, and colloidal stability analysis.
  • Biodegradability was assessed through hydrolysis of PLA grafts and enzymatic degradation of the dextran backbone.

Main Results:

  • The study successfully prepared dextran-coated polyester nanoparticles with tunable characteristics.
  • Nanoparticle properties, including size and stability, were significantly influenced by the length and number of polylactide grafts on the dextran backbone.
  • The developed nanoparticles exhibited complete biodegradability, with controlled hydrolysis of the polylactide component and enzymatic degradation of the dextran component.

Conclusions:

  • Polysaccharide-covered polyester nanoparticles can be effectively prepared using polylactide-grafted dextran copolymers as stabilizers.
  • The structural features of the graft copolymers directly impact nanoparticle properties and colloidal stability.
  • These biodegradable nanoparticles hold promise for advanced drug delivery systems and other biomedical applications.