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Published on: June 1, 2019
Pathological examination with two-millimetre serial sectioning for sentinel lymph node biopsies in breast cancer
T Ishikawa1, T Sasaki, E Miyajima
1Department of General Surgery, Yokohama City University Medical Center, Yokohama, Japan. tishik@urahp.yokohama-cu.ac.jp
Aims:
To compare enhanced pathology with serial sectioning and the transcription-reverse transcription concerted reaction (TRC) for detecting sentinel node (SN) metastasis in breast cancer cases.
Methods:
In total, 115 SN samples from 32 breast cancer cases were investigated by pathological examination with 2.0-mm serial sectioning and by quantitative analysis of carcinoembryonic antigen messenger RNA with the TRC.
Results:
The results were concordant in 98.3% of these cases. Two histologically metastatic nodes tested negative by TRC, whereas none tested positive by TRC alone.
Conclusion:
Pathological examination with 2-mm sectioning showed superior performance to TRC under the study conditions.
