[Resistance in influenza viruses]
Olav Hungnes1, Susanne Gjeruldsen Dudman
1Avdeling for virologi, Nasjonalt folkehelseinstitutt, Postboks 4404 Nydalen, 0403 Oslo. olav.hungnes@fhi.no
Summary
Antiviral resistance to influenza drugs like oseltamivir is increasing. Continuous monitoring of antiviral susceptibility and development of new treatments are crucial for pandemic preparedness.
Area of Science:
- Virology
- Infectious Diseases
- Antimicrobial Resistance
Context:
- Influenza virus infections are managed with antiviral drugs, yet their use in Norway has been limited.
- Antiviral drugs are vital for pandemic preparedness due to potential vaccine access delays.
- Older influenza drugs faced significant resistance; newer neuraminidase inhibitors showed fewer issues until recently.
Purpose:
- To review the current landscape of antiviral drug resistance in influenza viruses.
- To highlight the importance of resistance surveillance for effective influenza treatment strategies.
- To emphasize the need for ongoing monitoring and development of new antiviral therapies.
Summary:
- Widespread resistance to neuraminidase inhibitors, specifically oseltamivir, emerged during the 2007/2008 influenza season.
- Resistance surveillance is critical for selecting appropriate empiric influenza treatment during pandemics.
- The growing problem of antiviral resistance necessitates continuous monitoring and the development of novel drugs and treatment regimens.
Impact:
- Informing public health strategies for influenza management and pandemic response.
- Guiding the selection of antiviral therapies based on real-time resistance data.
- Driving research and development for next-generation influenza antivirals.
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