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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 27, 2026

Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

Merkel cell carcinoma.

J C Becker1, D Schrama, R Houben

  • 1Department of Dermatology, Venereology and Allergy, University of Würzburg, Josef-Schneider-Str. 2, Bld. D8, 97080 Würzburg, Germany. becker_jc@klinik.uni-wuerzburg.de

Cellular and Molecular Life Sciences : CMLS
|November 22, 2008
PubMed
Summary
This summary is machine-generated.

Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer. Research indicates polyomavirus integration in MCC cells may impact future treatments.

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Published on: June 7, 2019

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer with a high mortality rate.
  • MCC incidence is increasing, with an estimated 1,500 new cases in the USA in 2008.
  • The exact pathogenesis of MCC remains incompletely understood.

Purpose of the Study:

  • To investigate the molecular pathogenesis of Merkel cell carcinoma.
  • To explore the roles of Wnt, MAPK, and Akt signaling pathways in MCC.
  • To examine potential aberrations in the p14ARF/p53/RB tumor suppressor network.

Main Methods:

  • Analysis of signaling pathways (Wnt, MAPK, Akt) in MCC.
  • Investigation of the p14ARF/p53/RB tumor suppressor network.
  • Detection of viral integration in MCC genomes.

Main Results:

  • Findings suggest involvement of Wnt, MAPK, and Akt signaling in MCC.
  • Potential aberrations within the p14ARF/p53/RB tumor suppressor network were identified.
  • Frequent integration of a polyomavirus into MCC cell genomes prior to tumor development was demonstrated.

Conclusions:

  • Understanding MCC pathogenesis involves key signaling pathways and tumor suppressor networks.
  • Polyomavirus integration is a significant finding with potential therapeutic implications for MCC.