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Related Experiment Video

Updated: Jun 27, 2026

Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
05:18

Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome

Published on: May 26, 2023

Pulse steroid therapy.

Aditi Sinha1, Arvind Bagga

  • 1Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences New Delhi, Ansari Nagar, New Delhi, India.

Indian Journal of Pediatrics
|November 22, 2008
PubMed
Summary
This summary is machine-generated.

High-dose intravenous corticosteroids offer a less toxic alternative for managing pediatric inflammatory and autoimmune diseases. While effective, these potent therapies require careful monitoring due to significant potential side effects.

Related Experiment Videos

Last Updated: Jun 27, 2026

Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
05:18

Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome

Published on: May 26, 2023

Area of Science:

  • Pediatric Nephrology
  • Pediatric Rheumatology
  • Pediatric Neurology
  • Immunology

Background:

  • Intravenous supra-pharmacological corticosteroid doses are utilized for various inflammatory and autoimmune conditions.
  • Their cumulative toxicity is lower than sustained low-dose steroid therapy.
  • Action is presumed to be via non-genomic cellular mechanisms.

Purpose of the Study:

  • To review the indications and efficacy of high-dose intravenous corticosteroids in pediatric inflammatory and autoimmune diseases.
  • To highlight the associated side effects and the necessity of monitoring.

Main Methods:

  • Review of current clinical practice and literature regarding intravenous supra-pharmacological corticosteroid use in children.
  • Analysis of common indications, efficacy of methylprednisolone and dexamethasone, and associated adverse events.

Main Results:

  • Common pediatric indications include nephrotic syndrome, glomerulonephritis, vasculitis, lupus erythematosus, and allograft rejection.
  • Methylprednisolone and dexamethasone demonstrate comparable efficacy across most conditions.
  • Significant side effects encompass hypertension, infections, dyselectrolytemia, and behavioral changes.

Conclusions:

  • High-dose intravenous corticosteroids are a valuable therapeutic option for severe pediatric inflammatory and autoimmune conditions.
  • Careful patient monitoring is crucial to manage potential adverse effects effectively.
  • These treatments offer a less toxic profile compared to long-term lower-dose steroid regimens.