Enhanced dissolution of ibuprofen using solid dispersion with poloxamer 407.

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Background:

• Ibuprofen exhibits poor aqueous solubility, limiting its oral bioavailability.
• Solid dispersions (SDs) are a strategy to enhance the dissolution and absorption of poorly soluble drugs.

Purpose of the Study:

• To prepare and characterize ibuprofen solid dispersions (SDs) using poloxamer P 407.
• To evaluate the impact of SD formulation on ibuprofen solubility, dissolution, and in-vivo oral absorption in rats.

Main Methods:

• Ibuprofen SDs were prepared and characterized using SEM, DSC, and FTIR.
• In-vitro dissolution and in-vivo pharmacokinetic studies in rats were conducted.

Main Results:

• SEM confirmed the formation of effective SDs by observing altered surface properties.
• DSC and FTIR provided evidence of drug-polymer interactions.
• SDs demonstrated significantly improved ibuprofen solubility and in-vitro release rates.
• In-vivo studies showed increased AUC and C(max), and decreased T(max) for ibuprofen from SDs compared to pure drug.

Conclusions:

• Ibuprofen SDs prepared with poloxamer P 407 effectively enhance drug solubility and dissolution.
• The improved dissolution translates to enhanced oral absorption and pharmacokinetic profile in rats.
• Poloxamer P 407 is a promising carrier for developing ibuprofen SDs to improve bioavailability.