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Updated: Jun 27, 2026
07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
[Prognostic factors for oral squamous cell carcinoma]
A W Eckert1, M H W Lautner, R Dempf
1Universitätsklinik und Poliklinik für Mund-, Kiefer-und Plastische Gesichtschirurgie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Strasse 40, Halle/Saale, Germany. aw.eckert.wissenschaft@web.de
Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|November 22, 2008
Summary
Prognostic factors significantly impact oral squamous cell carcinoma (OSCC) survival. Tumor size and lymph node metastasis are key determinants of patient outcomes in OSCC.
Area of Science:
- Oncology
- Oral Medicine
- Pathology
Context:
- Oral squamous cell carcinoma (OSCC) is a prevalent malignancy.
- Accurate prognostic factors are crucial for patient management and treatment planning.
- Understanding survival determinants aids in developing targeted therapeutic strategies.
Purpose:
- To identify and analyze key prognostic factors influencing overall survival in patients with primary oral squamous cell carcinoma (OSCC).
- To correlate clinicopathological features such as tumor stage, lymph node metastasis, and tumor grade with 5-year survival rates.
- To provide data supporting improved prognostic models for OSCC.
Summary:
- A retrospective analysis of 99 primary OSCC patients examined tumor-node-metastasis (TNM) stage, tumor grade, and 5-year survival.
- Overall 5-year survival was 57.3%. Survival rates were significantly associated with tumor size (T stage) and lymph node involvement (N stage).
- Highly differentiated tumors showed better survival (78.9%) compared to poorly differentiated ones (48.9%). Tumor size and lymph node status were identified as decisive prognostic factors.
Impact:
- This study highlights the critical role of tumor size and lymph node metastasis in predicting OSCC patient survival.
- Findings can inform clinical decision-making, patient counseling, and the stratification of patients for clinical trials.
- Establishes a foundation for further research into refining prognostic indicators for oral cancer.
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