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Published on: June 23, 2022
Microbial transformation of testosterone by Rhizopus stolonifer and Fusarium lini
Amal Al-Aboudi1, Mohammad Yasin Mohammad, S Ghulam Musharraf
1Chemistry Department, University of Jordan, Amman, Jordan. alaboudi@ju.edu.jo
Abstract:
The microbial transformation of testosterone by the fungi Rhizopus stolonifer and Fusarium lini has been investigated for the first time. The bioconversion reactions observed from R. stolonifer included oxidation of a 17beta-hydroxyl group, a hydroxylation at equatorial 11alpha position, reduction of the double bond at C-4 with oxidation of the methylene at C-6 to the corresponding keto group, and lactonisation of ring D; the latter is the first report of this reaction by a Rhizopus species. Fusarium lini promoted 1-dehydrogenation of the steroid, which has been rarely observed in fungi cultures. The other routes of biotransformations included oxidation of the 17beta-hydroxyl group and the hydroxylation at 11alpha position. These reactions are not common for Fusarium species.
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